Folate:Active B12
Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
PRL (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
81.653013
|
1
|
<0.0001
|
***
|
|
folate_Active.B12
|
2.405026
|
1
|
0.1
|
ns
|
|
Study
|
5.359313
|
1
|
0.02
|
*
|
|
GA_samp
|
60.136224
|
1
|
<0.0001
|
***
|
|
folate_Active.B12:Study
|
7.831834
|
1
|
0.005
|
**
|
hPL (μg/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
6.7473777
|
1
|
0.009
|
**
|
|
folate_Active.B12
|
0.4492223
|
1
|
0.5
|
ns
|
|
Study
|
16.2494864
|
1
|
<0.0001
|
***
|
|
GA_samp
|
843.1941108
|
1
|
<0.0001
|
***
|
|
folate_Active.B12:Study
|
4.5843424
|
1
|
0.03
|
*
|
GH2 (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
198.6866206
|
1
|
<0.0001
|
***
|
|
folate_Active.B12
|
1.0610568
|
1
|
0.3
|
ns
|
|
Study
|
0.0121323
|
1
|
0.9
|
ns
|
|
GA_samp
|
468.3134903
|
1
|
<0.0001
|
***
|
|
folate_Active.B12:Study
|
2.2694976
|
1
|
0.1
|
ns
|
Insulin (uU/ml)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
folate_Active.B12
|
1
|
Inf
|
1.589
|
1.589
|
0.2
|
ns
|
|
3
|
Study
|
1
|
Inf
|
8.527
|
8.527
|
0.003
|
**
|
|
4
|
GA_samp
|
1
|
Inf
|
0.097
|
0.097
|
0.8
|
ns
|
|
2
|
folate_Active.B12:Study
|
1
|
Inf
|
1.432
|
1.432
|
0.2
|
ns
|
HOMA-IR
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
folate_Active.B12
|
1
|
Inf
|
1.851
|
1.851
|
0.2
|
ns
|
|
3
|
Study
|
1
|
Inf
|
14.060
|
14.060
|
0.0002
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
0.177
|
0.177
|
0.7
|
ns
|
|
2
|
folate_Active.B12:Study
|
1
|
Inf
|
1.383
|
1.383
|
0.2
|
ns
|
Glucose (mmol/L)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
folate_Active.B12
|
1
|
Inf
|
4.808
|
4.808
|
0.03
|
*
|
|
3
|
Study
|
1
|
Inf
|
41.897
|
41.897
|
<0.0001
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
1.163
|
1.163
|
0.3
|
ns
|
|
2
|
folate_Active.B12:Study
|
1
|
Inf
|
0.226
|
0.226
|
0.6
|
ns
|
Model summary
Ratio of Geometric means (95% CI)
PRL (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
15.95 (8.75, 29.04)
|
<0.0001
|
|
folate_Active.B12
|
1.00 (1.00, 1.00)
|
0.12
|
|
StudySTOP
|
0.77 (0.62, 0.96)
|
0.02
|
|
GA_samp
|
1.16 (1.12, 1.20)
|
<0.0001
|
|
folate_Active.B12:StudySTOP
|
1.00 (1.00, 1.00)
|
0.005
|
hPL (μg/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
1.54 (1.11, 2.14)
|
0.010
|
|
folate_Active.B12
|
1.00 (1.00, 1.00)
|
0.50
|
|
StudySTOP
|
1.28 (1.13, 1.44)
|
<0.0001
|
|
GA_samp
|
1.36 (1.33, 1.38)
|
<0.0001
|
|
folate_Active.B12:StudySTOP
|
1.00 (1.00, 1.00)
|
0.03
|
GH2 (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
0.05 (0.03, 0.07)
|
<0.0001
|
|
folate_Active.B12
|
1.00 (1.00, 1.00)
|
1.00
|
|
StudySTOP
|
1.06 (0.93, 1.20)
|
0.39
|
|
GA_samp
|
1.33 (1.30, 1.37)
|
<0.0001
|
Insulin (uU/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
16.90 (8.16, 35.02)
|
<0.0001
|
|
folate_Active.B12
|
1.00 (1.00, 1.00)
|
0.18
|
|
StudySTOP
|
0.71 (0.57, 0.90)
|
0.004
|
|
GA_samp
|
0.99 (0.95, 1.04)
|
0.78
|
HOMA-IR
|
Var
|
Effect
|
P
|
|
(Intercept)
|
4.29 (1.98, 9.31)
|
0.0002
|
|
folate_Active.B12
|
1.00 (1.00, 1.00)
|
0.15
|
|
StudySTOP
|
0.62 (0.48, 0.79)
|
0.0001
|
|
GA_samp
|
0.99 (0.94, 1.04)
|
0.69
|
Glucose (mmol/L)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
6.04 (5.16, 7.06)
|
<0.0001
|
|
folate_Active.B12
|
1.00 (1.00, 1.00)
|
0.004
|
|
StudySTOP
|
0.86 (0.83, 0.90)
|
<0.0001
|
|
GA_samp
|
0.99 (0.98, 1.00)
|
0.28
|
Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling.
Results are averaged over the levels of Folate:Active B12 ratio and may be misleading when interaction term is involved.
PRL (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
103.52216
|
9.538256
|
132.2925
|
86.27438
|
124.2181
|
|
STOP
|
95.26028
|
8.205226
|
102.5693
|
80.30054
|
113.0070
|
hPL (μg/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
90.58383
|
3.238948
|
255.1716
|
84.42475
|
97.19225
|
|
STOP
|
107.75515
|
3.443906
|
164.9170
|
101.16542
|
114.77411
|
GH2 (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
2.292618
|
0.0973988
|
309.6921
|
2.108763
|
2.492503
|
|
STOP
|
2.425090
|
0.0890729
|
203.7927
|
2.255676
|
2.607228
|
Insulin (uU/ml)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
14.69993
|
1.1456949
|
Inf
|
12.617509
|
17.12604
|
|
STOP
|
10.50458
|
0.6474221
|
Inf
|
9.309302
|
11.85333
|
HOMA-IR
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
3.557729
|
0.2993955
|
Inf
|
3.016764
|
4.195701
|
|
STOP
|
2.192979
|
0.1431559
|
Inf
|
1.929606
|
2.492300
|
Glucose (mmol/L)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
5.531632
|
0.0815836
|
Inf
|
5.374020
|
5.693867
|
|
STOP
|
4.765678
|
0.0585860
|
Inf
|
4.652224
|
4.881899
|
Comparisons
Effect for every 500 unit increase in Folate:Active B12 ratio.
|
Hormone
|
Contrast
|
Study
|
Ratio of Geometric means (95% CI)
|
P-value
|
|
PRL (ng/ml)
|
folate_Active.B121144.86 / folate_Active.B12644.86
|
SCOPE
|
0.96 (0.92, 1.01)
|
0.1
|
|
PRL (ng/ml)
|
folate_Active.B121144.86 / folate_Active.B12644.86
|
STOP
|
1.06 (1.01, 1.12)
|
0.02
|
|
hPL (μg/ml)
|
folate_Active.B121144.86 / folate_Active.B12644.86
|
SCOPE
|
1.01 (0.98, 1.04)
|
0.5
|
|
hPL (μg/ml)
|
folate_Active.B121144.86 / folate_Active.B12644.86
|
STOP
|
0.97 (0.94, 1.00)
|
0.02
|
|
GH2 (ng/ml)
|
folate_Active.B121144.86 / folate_Active.B12644.86
|
SCOPE
|
1.00 (0.98, 1.02)
|
1.0
|
|
GH2 (ng/ml)
|
folate_Active.B121144.86 / folate_Active.B12644.86
|
STOP
|
1.00 (0.98, 1.02)
|
1.0
|
|
Insulin (uU/ml)
|
folate_Active.B121144.86 / folate_Active.B12644.86
|
SCOPE
|
0.97 (0.93, 1.01)
|
0.2
|
|
Insulin (uU/ml)
|
folate_Active.B121144.86 / folate_Active.B12644.86
|
STOP
|
0.97 (0.93, 1.01)
|
0.2
|
|
HOMA-IR
|
folate_Active.B121144.86 / folate_Active.B12644.86
|
SCOPE
|
0.97 (0.93, 1.01)
|
0.1
|
|
HOMA-IR
|
folate_Active.B121144.86 / folate_Active.B12644.86
|
STOP
|
0.97 (0.93, 1.01)
|
0.1
|
|
Glucose (mmol/L)
|
folate_Active.B121144.86 / folate_Active.B12644.86
|
SCOPE
|
0.99 (0.99, 1.00)
|
0.004
|
|
Glucose (mmol/L)
|
folate_Active.B121144.86 / folate_Active.B12644.86
|
STOP
|
0.99 (0.99, 1.00)
|
0.004
|
Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)

Diagnositcs for hPL (μg/ml)

Diagnositcs for GH2 (ng/ml)

Diagnositcs for Insulin (uU/ml)

Diagnositcs for HOMA-IR

Diagnositcs for Glucose (mmol/L)
